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A conditional inducible JAK2V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression.
Chapeau, Emilie A; Mandon, Emeline; Gill, Jason; Romanet, Vincent; Ebel, Nicolas; Powajbo, Violetta; Andraos-Rey, Rita; Qian, Zhiyan; Kininis, Miltos; Zumstein-Mecker, Sabine; Ito, Moriko; Hynes, Nancy E; Tiedt, Ralph; Hofmann, Francesco; Eshkind, Leonid; Bockamp, Ernesto; Kinzel, Bernd; Mueller, Matthias; Murakami, Masato; Baffert, Fabienne; Radimerski, Thomas.
Afiliação
  • Chapeau EA; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Mandon E; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Gill J; Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
  • Romanet V; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Ebel N; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Powajbo V; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Andraos-Rey R; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Qian Z; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Kininis M; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Zumstein-Mecker S; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Ito M; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Hynes NE; Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
  • Tiedt R; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Hofmann F; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Eshkind L; Institute for Translational Immunology and Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
  • Bockamp E; Institute for Translational Immunology and Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
  • Kinzel B; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Mueller M; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Murakami M; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Baffert F; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
  • Radimerski T; Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.
PLoS One ; 14(10): e0221635, 2019.
Article em En | MEDLINE | ID: mdl-31600213
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Regulação da Expressão Gênica / Transgenes / Janus Quinase 2 / Transtornos Mieloproliferativos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suíça
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Regulação da Expressão Gênica / Transgenes / Janus Quinase 2 / Transtornos Mieloproliferativos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suíça