Molecular forms of immunoactive atrial natriuretic peptide in the rat hypothalamus and atrium.
Biochem Biophys Res Commun
; 129(3): 671-8, 1985 Jun 28.
Article
em En
| MEDLINE
| ID: mdl-3160349
ABSTRACT
Acid extracts of rat hypothalamus and atrium were prepared by a procedure previously shown to minimize proteolytic degradation of peptides. The majority of the immunoactive material in the atrial extracts had a molecular weight of approximately 9,000 to 15,000 daltons, while that in the hypothalamic extracts had a molecular weight of about 1,500 to 1,800 daltons. The major molecular weight forms of atrial natriuretic peptide from each extract were further distinguishable when analyzed by RP-HPLC. These results suggest that small peptides such as atriopeptins I, II, and III, may not be authentic post-translational processing products in the atrium, and that the hypothalamus and atrium may differentially cleave pro-atrial natriuretic peptide to form tissue-specific products.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipotálamo
/
Proteínas Musculares
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
1985
Tipo de documento:
Article