Enhanced Oral Bioavailability and Anti-Echinococcosis Efficacy of Albendazole Achieved by Optimizing the "Spring" and "Parachute".

Hu, Chunhui; Liu, Zhengsheng; Liu, Chengyu; Li, Jianhua; Wang, Zhixin; Xu, Liuting; Chen, Cen; Fan, Haining; Qian, Feng

Hu, Chunhui; Liu, Zhengsheng; Liu, Chengyu; Li, Jianhua; Wang, Zhixin; Xu, Liuting; Chen, Cen; Fan, Haining; Qian, Feng.

Afiliação

Hu C; School of Pharmaceutical Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, P. R. China.
Liu Z; Medical College, Qinghai University, Qinghai 810001, P. R. China.
Liu C; School of Pharmaceutical Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, P. R. China.
Li J; School of Pharmaceutical Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, P. R. China.
Chen C; Crystal Pharmatech Co., Ltd., B4-101, Biobay, 218 Xinghu Street, Suzhou Industrial Park, Jiangsu 215123, P. R. China.
Fan H; Crystal Pharmatech Co., Ltd., B4-101, Biobay, 218 Xinghu Street, Suzhou Industrial Park, Jiangsu 215123, P. R. China.

Mol Pharm ; 16(12): 4978-4986, 2019 12 02.

Article em En | MEDLINE | ID: mdl-31613633

Assuntos

Albendazol/uso terapêutico; Equinococose/tratamento farmacológico; Albendazol/química; Animais; Cães; Echinococcus multilocularis/efeitos dos fármacos; Echinococcus multilocularis/patogenicidade; Concentração de Íons de Hidrogênio; Cinética; Masculino; Microscopia Eletrônica de Varredura; Polímeros/química; Ratos; Ratos Sprague-Dawley; Solubilidade

Palavras-chave

albendazole; anti-echinococcosis efficacy; hepatic alveolar echinococcosis; oral bioavailability; supersaturation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Albendazol / Equinococose Limite: Animals Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article

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