Cigarette smoke inhalation decreases alpha 1-antitrypsin activity in rat lung.
Science
; 206(4424): 1313-4, 1979 Dec 14.
Article
em En
| MEDLINE
| ID: mdl-316187
ABSTRACT
Brief inhalation exposure of rats to three or six puffs of cigarette smoke significantly decreases elastase inhibitory capacity per milligram of alpha 1-antitrypsin in lung lavage fluid. This effect is not observed in ozone-tolerant rats and can be reversed by treating the lung lavage fluid from smoke-exposed rats with reducing agents. Samples of human serum obtained immediately after smoking also show decreased elastase inhibitory capacity per milligram of alpha 1-antitrypsin. Again, elastase inhibitory capacity can be restored by treatment with a reducing agent. Cigarette smoking may cause emphysema by inactivating alpha 1-antitrypsin through oxidation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fumar
/
Alfa 1-Antitripsina
/
Pulmão
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1979
Tipo de documento:
Article