Transcriptional Signature Derived from Murine Tumor-Associated Macrophages Correlates with Poor Outcome in Breast Cancer Patients.

Tuit, Sander; Salvagno, Camilla; Kapellos, Theodore S; Hau, Cheei-Sing; Seep, Lea; Oestreich, Marie; Klee, Kathrin; de Visser, Karin E; Ulas, Thomas; Schultze, Joachim L

Tuit, Sander; Salvagno, Camilla; Kapellos, Theodore S; Hau, Cheei-Sing; Seep, Lea; Oestreich, Marie; Klee, Kathrin; de Visser, Karin E; Ulas, Thomas; Schultze, Joachim L.

Afiliação

Tuit S; Genomics and Immunoregulation, LIMES Institute, University of Bonn, 53113 Bonn, Germany; Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands.
Salvagno C; Division of Tumor Biology & Immunology, Oncode Institute, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
Kapellos TS; Genomics and Immunoregulation, LIMES Institute, University of Bonn, 53113 Bonn, Germany.
Hau CS; Division of Tumor Biology & Immunology, Oncode Institute, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
Seep L; Genomics and Immunoregulation, LIMES Institute, University of Bonn, 53113 Bonn, Germany.
Oestreich M; Genomics and Immunoregulation, LIMES Institute, University of Bonn, 53113 Bonn, Germany.
Klee K; Genomics and Immunoregulation, LIMES Institute, University of Bonn, 53113 Bonn, Germany.
de Visser KE; Division of Tumor Biology & Immunology, Oncode Institute, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands. Electronic address: k.d.visser@nki.nl.
Ulas T; Genomics and Immunoregulation, LIMES Institute, University of Bonn, 53113 Bonn, Germany.
Schultze JL; Genomics and Immunoregulation, LIMES Institute, University of Bonn, 53113 Bonn, Germany; Platform for Single Cell Genomics and Epigenomics (PRECISE) at the German Center for Neurodegenerative Diseases and the University of Bonn, 53127 Bonn, Germany. Electronic address: j.schultze@uni-bonn.de.

Cell Rep ; 29(5): 1221-1235.e5, 2019 10 29.

Article em En | MEDLINE | ID: mdl-31665635

Assuntos

Neoplasias da Mama/genética; Neoplasias da Mama/patologia; Perfilação da Expressão Gênica; Macrófagos/metabolismo; Neoplasias Mamárias Animais/patologia; Transcrição Gênica; Animais; Carcinogênese/genética; Carcinogênese/patologia; Modelos Animais de Doenças; Feminino; Regulação Neoplásica da Expressão Gênica; Humanos; Neoplasias Mamárias Animais/genética; Camundongos Endogâmicos BALB C; Camundongos Transgênicos; Fenótipo; Prognóstico; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Análise de Sobrevida; Transcriptoma/genética; Resultado do Tratamento

Palavras-chave

breast cancer; clinical outcome prediction; co-expression network analysis; human; innate immunity; invasive lobular carcinoma; mouse model; transcriptome; tumor-associated macrophage

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transcrição Gênica / Neoplasias da Mama / Neoplasias Mamárias Animais / Perfilação da Expressão Gênica / Macrófagos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda

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