A Live Attenuated Influenza Vaccine Elicits Enhanced Heterologous Protection When the Internal Genes of the Vaccine Are Matched to Those of the Challenge Virus.

Smith, Andrew; Rodriguez, Laura; El Ghouayel, Maya; Nogales, Aitor; Chamberlain, Jeffrey M; Sortino, Katherine; Reilly, Emma; Feng, Changyong; Topham, David J; Martínez-Sobrido, Luis; Dewhurst, Stephen

Smith, Andrew; Rodriguez, Laura; El Ghouayel, Maya; Nogales, Aitor; Chamberlain, Jeffrey M; Sortino, Katherine; Reilly, Emma; Feng, Changyong; Topham, David J; Martínez-Sobrido, Luis; Dewhurst, Stephen.

Afiliação

Smith A; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
Rodriguez L; Medical Scientist Training Program, University of Rochester, Rochester, New York, USA.
El Ghouayel M; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
Nogales A; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
Chamberlain JM; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
Sortino K; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
Reilly E; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
Feng C; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
Topham DJ; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, USA.
Martínez-Sobrido L; Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, USA.
Dewhurst S; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.

J Virol ; 94(4)2020 01 31.

Article em En | MEDLINE | ID: mdl-31748399

Assuntos

Vírus da Influenza A/genética; Vacinas contra Influenza/genética; Influenza Humana/genética; Animais; Anticorpos Neutralizantes; Anticorpos Antivirais/imunologia; Cães; Feminino; Células HEK293; Humanos; Imunogenicidade da Vacina/imunologia; Vírus da Influenza A Subtipo H1N1/genética; Vírus da Influenza A Subtipo H1N1/imunologia; Vírus da Influenza A Subtipo H2N2/genética; Vírus da Influenza A Subtipo H2N2/imunologia; Vírus da Influenza A/imunologia; Vacinas contra Influenza/imunologia; Influenza Humana/imunologia; Influenza Humana/virologia; Células Madin Darby de Rim Canino; Camundongos; Camundongos Endogâmicos C57BL; Vacinas Atenuadas/imunologia

Palavras-chave

IIV; LAIV; MDV; heterologous immunity and protection; inactivated influenza vaccine; influenza; live attenuated influenza vaccine; master donor virus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Vacinas contra Influenza / Influenza Humana Limite: Animals / Female / Humans Idioma: En Revista: J Virol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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