Design, synthesis and biological evaluation of 8-(2-amino-1-hydroxyethyl)-6-hydroxy-1,4-benzoxazine-3(4H)-one derivatives as potent ß<sub>2</sub>-adrenoceptor agonists.

Yi, Ce; Xing, Gang; Wang, Siqi; Li, Xiaoran; Liu, Yichuang; Li, Jinyan; Lin, Bin; Woo, Anthony Yiu-Ho; Zhang, Yuyang; Pan, Li; Cheng, Maosheng

Design, synthesis and biological evaluation of 8-(2-amino-1-hydroxyethyl)-6-hydroxy-1,4-benzoxazine-3(4H)-one derivatives as potent ß₂-adrenoceptor agonists.

Yi, Ce; Xing, Gang; Wang, Siqi; Li, Xiaoran; Liu, Yichuang; Li, Jinyan; Lin, Bin; Woo, Anthony Yiu-Ho; Zhang, Yuyang; Pan, Li; Cheng, Maosheng.

Afiliação

Yi C; Department of Medicinal Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xing G; Department of Medicinal Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wang S; Department of Pharmacology, School of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Li X; Department of Pharmacology, School of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liu Y; Department of Medicinal Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Li J; Department of Medicinal Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Lin B; Department of Medicinal Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Woo AY; Department of Pharmacology, School of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang Y; Department of Pharmacology, School of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Pan L; Department of Medicinal Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: p
Cheng M; Department of Medicinal Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: m

Bioorg Med Chem ; 28(1): 115178, 2020 01 01.

Article em En | MEDLINE | ID: mdl-31753798

Assuntos

Agonistas Adrenérgicos beta/farmacologia; Benzoxazinas/farmacologia; Desenho de Fármacos; Receptores Adrenérgicos beta 2/metabolismo; Agonistas Adrenérgicos beta/síntese química; Agonistas Adrenérgicos beta/química; Animais; Benzoxazinas/síntese química; Benzoxazinas/química; Relação Dose-Resposta a Droga; Cobaias; Células HEK293; Humanos; Modelos Moleculares; Estrutura Molecular; Relação Estrutura-Atividade; Traqueia/efeitos dos fármacos; Traqueia/metabolismo

Palavras-chave

Asthma; COPD; Isoprenaline; Olodaterol; Salmeterol; ß(2)-adrenoceptor agonist

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Receptores Adrenérgicos beta 2 / Agonistas Adrenérgicos beta / Benzoxazinas Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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