The RNA-binding protein FMRP facilitates the nuclear export of <i>N</i><sup>6</sup>-methyladenosine-containing mRNAs.

Hsu, Phillip J; Shi, Hailing; Zhu, Allen C; Lu, Zhike; Miller, Nimrod; Edens, Brittany M; Ma, Yongchao C; He, Chuan

The RNA-binding protein FMRP facilitates the nuclear export of N⁶-methyladenosine-containing mRNAs.

Hsu, Phillip J; Shi, Hailing; Zhu, Allen C; Lu, Zhike; Miller, Nimrod; Edens, Brittany M; Ma, Yongchao C; He, Chuan.

Afiliação

Hsu PJ; Department of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637.
Shi H; Medical Scientist Training Program/Committee on Immunology, University of Chicago, Chicago, Illinois 60637.
Zhu AC; Department of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637.
Lu Z; Department of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637.
Miller N; Medical Scientist Training Program/Committee on Cancer Biology, University of Chicago, Chicago, Illinois 60637.
Edens BM; Department of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637.
Ma YC; Departments of Pediatrics, Neurology and Physiology, Northwestern University Feinberg School of Medicine, Anne and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611.
He C; Departments of Pediatrics, Neurology and Physiology, Northwestern University Feinberg School of Medicine, Anne and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611.

J Biol Chem ; 294(52): 19889-19895, 2019 12 27.

Article em En | MEDLINE | ID: mdl-31753916

Assuntos

Adenosina/análogos & derivados; Proteína do X Frágil da Deficiência Intelectual/metabolismo; RNA Mensageiro/metabolismo; Transporte Ativo do Núcleo Celular; Adenosina/metabolismo; Animais; Sítios de Ligação; Núcleo Celular/metabolismo; Córtex Cerebral/metabolismo; Proteína do X Frágil da Deficiência Intelectual/antagonistas & inibidores; Proteína do X Frágil da Deficiência Intelectual/genética; Síndrome do Cromossomo X Frágil/metabolismo; Síndrome do Cromossomo X Frágil/patologia; Células HEK293; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Interferência de RNA; Estabilidade de RNA; RNA Mensageiro/química; RNA Interferente Pequeno/metabolismo

Palavras-chave

FMRP; Fmr1 KO mice; N6-methyladenosine (m6A); RNA metabolism; RNA methylation; RNA-binding protein; fragile X mental retardation protein (FMRP); gene regulation; mouse; mouse brain; neurological disease; nuclear RNA; nuclear RNA export; post-transcriptional modification

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Adenosina / Proteína do X Frágil da Deficiência Intelectual Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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