Lateralization of Insular Ischemic Stroke is Not Associated With Any Stroke Clinical Outcomes: The Athens Stroke Registry.
J Stroke Cerebrovasc Dis
; 29(2): 104529, 2020 Feb.
Article
em En
| MEDLINE
| ID: mdl-31806455
ABSTRACT
BACKGROUND:
Controversial evidence suggests that right insular stroke may be associated with worse outcomes compared to the left insular ischemic lesion.OBJECTIVES:
We investigated whether lateralization of insular stroke is associated with early and late outcome in terms of in-hospital complications, stroke recurrence, cardiovascular events, and death.METHODS:
Data were prospectively collected from the Athens Stroke Registry. Insular cortex involvement was identified based on brain CT scans or MRI images. Patients were followed up prospectively at 1, 3, 6 months after hospital discharge and yearly thereafter up to 5-years or until death. The assessed outcomes were in-hospital complications, functional outcome assessed by the modified Rankin Scale, stroke recurrence, cardiovascular events, and death. Cox-regression analysis was performed to estimate the cumulative probability of each outcome according to the lateralization of insular strokes.RESULTS:
Among the 1212 patients, 650 had left insular stroke involvement and 562 had right. New onset of in-hospital atrial fibrillation was similar between right and left insular strokes (11.6% versus 12.9%, P = .484). During the 5-year follow-up sudden death occurred in 21 (3.7%) patients with right insular compared to 30 (4.6%) with left insular stroke (P = .476). There was no difference between left and right insular strokes regarding mortality (adjusted odds ratio [OR] .92, 95% confidence interval [CI] .80-1.06), stroke recurrence (4.3% versus 4.9%; adjusted OR .81 95% CI .58-1.13), cardiovascular events, and sudden death (adjusted OR .99, 95% CI .76-1.29) and on death and dependency (adjusted OR .88, 95% CI .75-1.02) during a 5-year follow up.CONCLUSIONS:
Lateralization of insular ischemic stroke involvement is not associated with stroke outcomes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
/
Isquemia Encefálica
/
Acidente Vascular Cerebral
/
Lateralidade Funcional
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Stroke Cerebrovasc Dis
Assunto da revista:
ANGIOLOGIA
/
CEREBRO
Ano de publicação:
2020
Tipo de documento:
Article