Safety and tolerability of experimental hookworm infection in humans with metabolic disease: study protocol for a phase 1b randomised controlled clinical trial.

Pierce, Doris; Merone, Lea; Lewis, Chris; Rahman, Tony; Croese, John; Loukas, Alex; McDonald, Malcolm; Giacomin, Paul; McDermott, Robyn

Pierce, Doris; Merone, Lea; Lewis, Chris; Rahman, Tony; Croese, John; Loukas, Alex; McDonald, Malcolm; Giacomin, Paul; McDermott, Robyn.

Afiliação

Pierce D; Centre for Molecular Therapeutics, Australian Institute of Tropical Health & Medicine, James Cook University, Building E5, Cairns Campus, 14-88 McGregor Rd Smithfield, Cairns, QLD, 4878, Australia. doris.pierce@my.jcu.edu.au.
Merone L; Centre for Chronic Disease Prevention, Australian Institute of Tropical Health & Medicine, James Cook University, QLD, Cairns, Australia.
Lewis C; Centre for Chronic Disease Prevention, Australian Institute of Tropical Health & Medicine, James Cook University, QLD, Cairns, Australia.
Rahman T; The Prince Charles Hospital, QLD, Brisbane, Australia.
Croese J; The Prince Charles Hospital, QLD, Brisbane, Australia.
Loukas A; Centre for Molecular Therapeutics, Australian Institute of Tropical Health & Medicine, James Cook University, Building E5, Cairns Campus, 14-88 McGregor Rd Smithfield, Cairns, QLD, 4878, Australia.
McDonald M; Centre for Chronic Disease Prevention, Australian Institute of Tropical Health & Medicine, James Cook University, QLD, Cairns, Australia.
Giacomin P; Centre for Molecular Therapeutics, Australian Institute of Tropical Health & Medicine, James Cook University, Building E5, Cairns Campus, 14-88 McGregor Rd Smithfield, Cairns, QLD, 4878, Australia.
McDermott R; Centre for Chronic Disease Prevention, Australian Institute of Tropical Health & Medicine, James Cook University, QLD, Cairns, Australia.

BMC Endocr Disord ; 19(1): 136, 2019 Dec 11.

Article em En | MEDLINE | ID: mdl-31829172

Assuntos

Síndrome Metabólica/terapia; Necatoríase; Obesidade/complicações; Terapia com Helmintos/métodos; Adolescente; Adulto; Animais; Diabetes Mellitus Tipo 2/prevenção & controle; Método Duplo-Cego; Fezes/microbiologia; Feminino; Microbioma Gastrointestinal/fisiologia; Humanos; Imunomodulação; Larva; Masculino; Síndrome Metabólica/imunologia; Síndrome Metabólica/microbiologia; Pessoa de Meia-Idade; Necator americanus; Necatoríase/imunologia; Necatoríase/microbiologia; Placebos; Queensland; Terapia com Helmintos/efeitos adversos; Resultado do Tratamento

Palavras-chave

Human microbiota; Metabolic syndrome; Necator americanus; Obesity; Type 2 diabetes mellitus; Type 2 immune response

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome Metabólica / Terapia com Helmintos / Necatoríase / Obesidade Tipo de estudo: Clinical_trials / Guideline / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged País/Região como assunto: Oceania Idioma: En Revista: BMC Endocr Disord Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Austrália

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