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Role of c-Jun N-Terminal Kinases (JNKs) in Epilepsy and Metabolic Cognitive Impairment.
Busquets, Oriol; Ettcheto, Miren; Cano, Amanda; R Manzine, Patricia; Sánchez-Lopez, Elena; Espinosa-Jiménez, Triana; Verdaguer, Ester; Dario Castro-Torres, Rubén; Beas-Zarate, Carlos; X Sureda, Francesc; Olloquequi, Jordi; Auladell, Carme; Folch, Jaume; Camins, Antoni.
Afiliação
  • Busquets O; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain.
  • Ettcheto M; Department of Biochemistry and Biotechnology, Faculty of Medicine and Life Science, University Rovira i Virgili, 43201 Reus, Spain.
  • Cano A; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.
  • R Manzine P; Institute of Neuroscience (Neuro UB), University of Barcelona, 08028 Barcelona, Spain.
  • Sánchez-Lopez E; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain.
  • Espinosa-Jiménez T; Department of Biochemistry and Biotechnology, Faculty of Medicine and Life Science, University Rovira i Virgili, 43201 Reus, Spain.
  • Verdaguer E; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.
  • Dario Castro-Torres R; Institute of Neuroscience (Neuro UB), University of Barcelona, 08028 Barcelona, Spain.
  • Beas-Zarate C; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.
  • X Sureda F; Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain.
  • Olloquequi J; Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain.
  • Auladell C; Department of Gerontology, Federal University of São Carlos (UFSCar), São Carlos 13565-905, Brazil.
  • Folch J; Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain.
  • Camins A; Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain.
Int J Mol Sci ; 21(1)2019 Dec 30.
Article em En | MEDLINE | ID: mdl-31905931
ABSTRACT
Previous studies have reported that the regulatory function of the different c-Jun N-terminal kinases isoforms (JNK1, JNK2, and JNK3) play an essential role in neurological disorders, such as epilepsy and metabolic-cognitive alterations. Accordingly, JNKs have emerged as suitable therapeutic strategies. In fact, it has been demonstrated that some unspecific JNK inhibitors exert antidiabetic and neuroprotective effects, albeit they usually show high toxicity or lack therapeutic value. In this sense, natural specific JNK inhibitors, such as Licochalcone A, are promising candidates. Nonetheless, research on the understanding of the role of each of the JNKs remains mandatory in order to progress on the identification of new selective JNK isoform inhibitors. In the present review, a summary on the current gathered data on the role of JNKs in pathology is presented, as well as a discussion on their potential role in pathologies like epilepsy and metabolic-cognitive injury. Moreover, data on the effects of synthetic small molecule inhibitors that modulate JNK-dependent pathways in the brain and peripheral tissues is reviewed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Quinases JNK Ativadas por Mitógeno / Epilepsia / Disfunção Cognitiva Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Quinases JNK Ativadas por Mitógeno / Epilepsia / Disfunção Cognitiva Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Espanha