The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine.

Dickson, Dane; Johnson, Jennifer; Bergan, Raymond; Owens, Rebecca; Subbiah, Vivek; Kurzrock, Razelle

Dickson, Dane; Johnson, Jennifer; Bergan, Raymond; Owens, Rebecca; Subbiah, Vivek; Kurzrock, Razelle.

Afiliação

Dickson D; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA; Taproot Health, Salt Lake City, UT, USA. Electronic address: dane.dickson@taprootco.com.
Johnson J; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Bergan R; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
Owens R; Taproot Health, Salt Lake City, UT, USA.
Subbiah V; University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kurzrock R; Moores Cancer Center, University of California at San Diego, San Diego, CA, USA.

Cell ; 180(1): 9-14, 2020 01 09.

Article em En | MEDLINE | ID: mdl-31951522

ABSTRACT

ABSTRACT

This commentary introduces a new clinical trial construct, the Master Observational Trial (MOT), which hybridizes the power of molecularly based master interventional protocols with the breadth of real-world data. The MOT provides a clinical venue to allow molecular medicine to rapidly advance, answers questions that traditional interventional trials generally do not address, and seamlessly integrates with interventional trials in both diagnostic and therapeutic arenas. The result is a more comprehensive data collection ecosystem in precision medicine.

Assuntos

Estudos Observacionais como Assunto/métodos; Medicina de Precisão/métodos; Projetos de Pesquisa/normas; Big Data; Protocolos de Ensaio Clínico como Assunto; Humanos; Terapia de Alvo Molecular/métodos; Terapia de Alvo Molecular/tendências; Estudos Observacionais como Assunto/normas

Palavras-chave

ROOT; evidence; innovation; master; protocol; quality; real-world data; trial

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Projetos de Pesquisa / Estudos Observacionais como Assunto / Medicina de Precisão Tipo de estudo: Guideline / Observational_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2020 Tipo de documento: Article

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