ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue.
Life Sci Alliance
; 3(3)2020 03.
Article
em En
| MEDLINE
| ID: mdl-32029570
ABSTRACT
Mitochondria play a central role in the function of brown adipocytes (BAs). Although mitochondrial biogenesis, which is indispensable for thermogenesis, is regulated by coordination between nuclear DNA transcription and mitochondrial DNA transcription, the molecular mechanisms of mitochondrial development during BA differentiation are largely unknown. Here, we show the importance of the ER-resident sensor PKR-like ER kinase (PERK) in the mitochondrial thermogenesis of brown adipose tissue. During BA differentiation, PERK is physiologically phosphorylated independently of the ER stress. This PERK phosphorylation induces transcriptional activation by GA-binding protein transcription factor α subunit (GABPα), which is required for mitochondrial inner membrane protein biogenesis, and this novel role of PERK is involved in maintaining the body temperatures of mice during cold exposure. Our findings demonstrate that mitochondrial development regulated by the PERK-GABPα axis is indispensable for thermogenesis in brown adipose tissue.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tecido Adiposo Marrom
/
EIF-2 Quinase
/
Retículo Endoplasmático
Limite:
Animals
Idioma:
En
Revista:
Life Sci Alliance
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Japão