Prospects for Therapies in Osteoarthritis.
Calcif Tissue Int
; 109(3): 339-350, 2021 09.
Article
em En
| MEDLINE
| ID: mdl-32055890
ABSTRACT
Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatments have limited efficacy and are associated with a number of side-effects, restricting the number of patients who can use them. New pharmacological therapies for managing OA are required and a number have been developed targeting different tissues in OA bone and cartilage, synovium and nerves. However, there has been overall limited success. Disease-modifying osteoarthritis drugs (DMOADs) are a putative class of therapies aimed at improving OA structural pathologies and consequent symptoms. Recent DMOAD studies have demonstrated some promising therapies but also provided new considerations for future trials.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
Limite:
Humans
Idioma:
En
Revista:
Calcif Tissue Int
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Reino Unido