Bioactive flavonoid dimers from Chinese dragon's blood, the red resin of Dracaena cochinchinensis.
Bioorg Chem
; 97: 103659, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32078940
ABSTRACT
Seven flavonoid dimers, biflavocochins A-G, together with six known compounds were isolated from the red resins of Dracaena cochinchinensis (Chinese dragon's blood). Their structures were elucidated based on extensive spectroscopic analysis. The absolute configurations of 1-7 was assigned by experimental and quantum chemical calculated ECD spectra, and that of 4 was further established by X-ray diffraction analysis using Cu Kα radiation. Compounds 1-3 are novel dimers of homoisoflavonoid and dihydrochalcone with a unique dibenzopyran ring. Compounds 2, 6, 7 exhibited moderate PTP1B inhibitory activities in an enzyme assay. Compound 1 showed neuroprotective effect on serum deficiency-induced cellular damage in PC12 cells.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
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Extratos Vegetais
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Fármacos Neuroprotetores
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Dracaena
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Inibidores Enzimáticos
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Proteína Tirosina Fosfatase não Receptora Tipo 1
Limite:
Animals
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Humans
Idioma:
En
Revista:
Bioorg Chem
Ano de publicação:
2020
Tipo de documento:
Article