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A drug discovery platform to identify compounds that inhibit EGFR triple mutants.
Saraon, Punit; Snider, Jamie; Kalaidzidis, Yannis; Wybenga-Groot, Leanne E; Weiss, Konstantin; Rai, Ankit; Radulovich, Nikolina; Drecun, Luka; Vuckovic, Nika; Vucetic, Adriana; Wong, Victoria; Thériault, Brigitte; Pham, Nhu-An; Park, Jin H; Datti, Alessandro; Wang, Jenny; Pathmanathan, Shivanthy; Aboualizadeh, Farzaneh; Lyakisheva, Anna; Yao, Zhong; Wang, Yuhui; Joseph, Babu; Aman, Ahmed; Moran, Michael F; Prakesch, Michael; Poda, Gennady; Marcellus, Richard; Uehling, David; Samarzija, Miroslav; Jakopovic, Marko; Tsao, Ming-Sound; Shepherd, Frances A; Sacher, Adrian; Leighl, Natasha; Akhmanova, Anna; Al-Awar, Rima; Zerial, Marino; Stagljar, Igor.
Afiliação
  • Saraon P; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  • Snider J; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  • Kalaidzidis Y; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
  • Wybenga-Groot LE; SPARC BioCentre, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Weiss K; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  • Rai A; Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, the Netherlands.
  • Radulovich N; Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Drecun L; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  • Vuckovic N; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  • Vucetic A; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  • Wong V; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  • Thériault B; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  • Pham NA; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Park JH; Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Datti A; Department of Pharmacology and Cancer Biology Institute, Yale University, New Haven, CT, USA.
  • Wang J; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.
  • Pathmanathan S; Network Biology Collaborative Centre, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
  • Aboualizadeh F; Department of Agriculture, Food, and Environmental Sciences, University of Perugia, Perugia, Italy.
  • Lyakisheva A; Network Biology Collaborative Centre, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
  • Yao Z; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  • Wang Y; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  • Joseph B; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  • Aman A; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  • Moran MF; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  • Prakesch M; Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Poda G; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Marcellus R; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Uehling D; Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Samarzija M; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  • Jakopovic M; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Tsao MS; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Shepherd FA; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
  • Sacher A; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Leighl N; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Akhmanova A; Department for Lung Diseases Jordanovac, Clinical Hospital Centre Zagreb, University of Zagreb, Zagreb, Croatia.
  • Al-Awar R; Department for Lung Diseases Jordanovac, Clinical Hospital Centre Zagreb, University of Zagreb, Zagreb, Croatia.
  • Zerial M; Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Stagljar I; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Nat Chem Biol ; 16(5): 577-586, 2020 05.
Article em En | MEDLINE | ID: mdl-32094923
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Ensaios de Triagem em Larga Escala Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Ensaios de Triagem em Larga Escala Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nat Chem Biol Assunto da revista: BIOLOGIA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá