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Speculations on the evolution of humoral adaptive immunity.
Horton, Miles B; Hawkins, Edwin D; Heinzel, Susanne; Hodgkin, Philip D.
Afiliação
  • Horton MB; Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Hawkins ED; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.
  • Heinzel S; Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Hodgkin PD; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.
Immunol Cell Biol ; 98(6): 439-448, 2020 07.
Article em En | MEDLINE | ID: mdl-32133683
The protection of a multicellular organism from infection, at both cell and humoral levels, has been a tremendous driver of gene selection and cellular response strategies. Here we focus on a critical event in the development of humoral immunity: The transition from principally innate responses to a system of adaptive cell selection, with all the attendant mechanical problems that must be solved in order for it to work effectively. Here we review recent advances, but our major goal is to highlight that the development of adaptive immunity resulted from the adoption, reuse and repurposing of an ancient, autonomous cellular program that combines and exploits three titratable cellular fate timers. We illustrate how this common cell machinery recurs and appears throughout biology, and has been essential for the evolution of complex organisms, at many levels of scale.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Evolução Biológica / Imunidade Adaptativa / Imunidade Humoral Limite: Humans Idioma: En Revista: Immunol Cell Biol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Evolução Biológica / Imunidade Adaptativa / Imunidade Humoral Limite: Humans Idioma: En Revista: Immunol Cell Biol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália