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Diabetes, Cognitive Decline, and Mild Cognitive Impairment Among Diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging Results (HCHS/SOL).
González, Hector M; Tarraf, Wassim; González, Kevin A; Fornage, Myriam; Zeng, Donglin; Gallo, Linda C; Talavera, Gregory A; Daviglus, Martha L; Lipton, Richard B; Kaplan, Robert; Ramos, Alberto R; Lamar, Melissa; Cai, Jianwen; DeCarli, Charles; Schneiderman, Neil.
Afiliação
  • González HM; Department of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, San Diego, CA hmg002@health.ucsd.edu.
  • Tarraf W; Institute of Gerontology and Department of Healthcare Sciences, Wayne State University, Detroit, MI.
  • González KA; Department of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, San Diego, CA hmg002@health.ucsd.edu.
  • Fornage M; University of Texas Health Science Center, Houston, TX.
  • Zeng D; Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
  • Gallo LC; Department of Psychology, San Diego State University, San Diego, CA.
  • Talavera GA; Department of Psychology, San Diego State University, San Diego, CA.
  • Daviglus ML; Institute for Minority Health Research, College of Medicine, University of Illinois at Chicago, Chicago, IL.
  • Lipton RB; Albert Einstein College of Medicine, New York, NY.
  • Kaplan R; Albert Einstein College of Medicine, New York, NY.
  • Ramos AR; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
  • Lamar M; Department of Neurology, University of Miami, Miami, FL.
  • Cai J; Institute for Minority Health Research, College of Medicine, University of Illinois at Chicago, Chicago, IL.
  • DeCarli C; Department of Psychiatry and Behavioral Sciences and Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.
  • Schneiderman N; Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Diabetes Care ; 43(5): 1111-1117, 2020 05.
Article em En | MEDLINE | ID: mdl-32139382
OBJECTIVE: Hispanics/Latinos are the largest ethnic/racial group in the U.S., have the highest prevalence of diabetes, and are at increased risk for neurodegenerative disorders. Currently, little is known about the relationship between diabetes and cognitive decline and disorders among diverse Hispanics/Latinos. The purpose of this study is to clarify these relationships in diverse middle-aged and older Hispanics/Latinos. RESEARCH DESIGN AND METHODS: The Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) is an ancillary study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). HCHS/SOL is a multisite (Bronx, NY; Chicago, IL; Miami, FL; and San Diego, CA), probability-sampled (i.e., representative of targeted populations), and prospective cohort study. Between 2016 and 2018, SOL-INCA enrolled diverse Hispanics/Latinos aged ≥50 years (n = 6,377). Global cognitive decline and mild cognitive impairment (MCI) were the primary outcomes. RESULTS: Prevalent diabetes at visit 1, but not incident diabetes at visit 2, was associated with significantly steeper global cognitive decline (ßGC = -0.16 [95% CI -0.25; -0.07]; P < 0.001), domain-specific cognitive decline, and higher odds of MCI (odds ratio 1.74 [95% CI 1.34; 2.26]; P < 0.001) compared with no diabetes in age- and sex-adjusted models. CONCLUSIONS: Diabetes was associated with cognitive decline and increased MCI prevalence among diverse Hispanics/Latinos, primarily among those with prevalent diabetes at visit 1. Our findings suggest that significant cognitive decline and MCI may be considered additional disease complications of diabetes among diverse middle-aged and older Hispanics/Latinos.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Hispânico ou Latino / Diabetes Mellitus / Disfunção Cognitiva / Envelhecimento Cognitivo Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Diabetes Care Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Hispânico ou Latino / Diabetes Mellitus / Disfunção Cognitiva / Envelhecimento Cognitivo Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Diabetes Care Ano de publicação: 2020 Tipo de documento: Article