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NK cells prevent T cell lymphoma development in T cell receptor-transgenic mice.
Dubois, Sigrid; Feigenbaum, Lionel; Waldmann, Thomas A; Müller, Jürgen R.
Afiliação
  • Dubois S; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Feigenbaum L; Science Applications International Corporation/Frederick, NCI-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA.
  • Waldmann TA; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Müller JR; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: muellerj@mail.nih.gov.
Cell Immunol ; 352: 104081, 2020 06.
Article em En | MEDLINE | ID: mdl-32143838
Mice that express a single transgenic T cell receptor have a low incidence of T cell lymphoma development. We investigated whether this tumor development is restricted by surveillance mechanisms that are exerted by IL-15-dependent cells. Lymphoma incidence was increased to between 30 and 60% when TCR transgenes were expressed in IL-15-deficient mice. Mice in which NK cells had been depleted genetically or with neutralizing antibodies allowed lymphoma growth while the absence of CD8 T cells was without consequence. Half of the emerged T cell lymphomas carried Notch1 mutations. The distinct phenotype of the lymphomas involved expression of PD1, CD30, CD24, the stress receptor ligand Mult1 and MHC class I down-regulation. NK cells were able to directly lyse lymphoma cells, and neutralizations of Mult1 and class I expression prevented NK cell degranulation. Together these data support an involvement of NK cells in tumor surveillance of nascent T cell lymphomas.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Receptores de Antígenos de Linfócitos T / Linfoma de Células T Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Immunol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Matadoras Naturais / Receptores de Antígenos de Linfócitos T / Linfoma de Células T Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Immunol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos