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Galtonosides A-E: Antiproliferative and Antiplasmodial Cholestane Glycosides from Galtonia regalis.
Du, Yongle; Martin, Brooke A; Valenciano, Ana Lisa; Clement, Jason A; Goetz, Michael; Cassera, Maria B; Kingston, David G I.
Afiliação
  • Du Y; Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, Virginia 24061, United States.
  • Martin BA; Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, Virginia 24061, United States.
  • Valenciano AL; Department of Biochemistry and Molecular Biology, and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, Georgia 30602, United States.
  • Clement JA; Natural Products Discovery Institute, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States.
  • Goetz M; Natural Products Discovery Institute, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States.
  • Cassera MB; Department of Biochemistry and Molecular Biology, and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, Georgia 30602, United States.
  • Kingston DGI; Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, Virginia 24061, United States.
J Nat Prod ; 83(4): 1043-1050, 2020 04 24.
Article em En | MEDLINE | ID: mdl-32227943
An extract of Galtonia regalis from the Natural Products Discovery Institute showed moderate antiplasmodial activity, with an IC50 value less than 1.25 µg/mL. The two known cholestane glycosides 1 and 2 and the five new cholestane glycosides galtonosides A-E (3-7) were isolated after bioassay-directed fractionation. The structures of the new compounds were determined by interpretation of their NMR and mass spectra. Among these compounds, galtonoside B (4) displayed the most potent antiplasmodial activity, with an IC50 value of 0.214 µM against the drug-resistant Dd2 strain of Plasmodium falciparum.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colestanos / Glicosídeos / Antimaláricos Limite: Humans Idioma: En Revista: J Nat Prod Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colestanos / Glicosídeos / Antimaláricos Limite: Humans Idioma: En Revista: J Nat Prod Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos