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Benzothiazepines, diltiazem and JTV-519, exert an anxiolytic-like effect via neurosteroid biosynthesis in mice.
Yoshizawa, Kazumi; Nakashima, Kozue; Tabuchi, Mizuho; Okumura, Ayano; Nakatake, Yuko; Yamada, Mitsuhiko; Tsuneoka, Yayoi; Higashi, Tatsuya.
Afiliação
  • Yoshizawa K; Laboratory of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan. Electronic address: yoshizawa-ph@rs.tus.ac.jp.
  • Nakashima K; Laboratory of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan.
  • Tabuchi M; Laboratory of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan.
  • Okumura A; Laboratory of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan.
  • Nakatake Y; Laboratory of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan; Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan.
  • Yamada M; Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan.
  • Tsuneoka Y; Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan.
  • Higashi T; Laboratory of Analytical and Bioanalytical Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan.
J Pharmacol Sci ; 143(3): 234-237, 2020 Jul.
Article em En | MEDLINE | ID: mdl-32249061
ABSTRACT
We investigated whether benzothiazepines could produce anxiolytic effects via allopregnanolone (ALLO) biosynthesis in mice. We compared the behavioral effects caused by benzothiazepines to those caused by carbamazepine and sodium valproate. We found that a pretreatment with finasteride (a 5 alpha-reductase inhibitor) suppressed carbamazepine-induced anxiolytic effects but not the effects of sodium valproate. Similar to carbamazepine, diltiazem and JTV-519 displayed anxiolytic effects that were suppressed by a pretreatment with finasteride. We clearly demonstrate that the benzothiazepines, diltiazem and JTV-519, exert an anxiolytic-like effect via ALLO biosynthesis in mice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pregnanolona / Tiazepinas / Ansiolíticos / Comportamento Animal / Diltiazem Limite: Animals Idioma: En Revista: J Pharmacol Sci Assunto da revista: FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pregnanolona / Tiazepinas / Ansiolíticos / Comportamento Animal / Diltiazem Limite: Animals Idioma: En Revista: J Pharmacol Sci Assunto da revista: FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article