Reevaluation of CBE value of BPA for hepatocytes.
Appl Radiat Isot
; 161: 109159, 2020 Jul.
Article
em En
| MEDLINE
| ID: mdl-32250845
ABSTRACT
The compound biological effectiveness (CBE) value of boronophenylalanine (BPA) for hepatocytes was experimentally determined for the purpose of boron neutron capture therapy (BNCT) for liver tumors. In this study, the critical reevaluation of previous value was performed. In previous experimental studies, the contribution of ß component of dose was ignored in the response curve to X-ray. X-ray dose cell survival curves were estimated by combining the α/ß values obtained in the ordinary micronucleus (MN) assay with the curve of MN-negative cell fraction (MN(-)F) to dose. This curve was compared to the boron neutron capture reaction (BNCR) dose curve. As a result, the CBE value was 4 at doses close to 0 Gy, decreasing to about 1.0 at doses close to 4.5 Gy. The new value is smaller than the previous value 4.2. This indicates that the bioequivalent dose to normal liver is lower than previously expected. Therefore, higher doses can be given to the tumor.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilalanina
/
Radiossensibilizantes
/
Compostos de Boro
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Terapia por Captura de Nêutron de Boro
/
Hepatócitos
Limite:
Animals
Idioma:
En
Revista:
Appl Radiat Isot
Assunto da revista:
MEDICINA NUCLEAR
/
SAUDE AMBIENTAL
Ano de publicação:
2020
Tipo de documento:
Article