SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion.

Han, Ying; Sun, Weiju; Ren, Di; Zhang, Jingwen; He, Zhibin; Fedorova, Julia; Sun, Xiaodong; Han, Fang; Li, Ji

Han, Ying; Sun, Weiju; Ren, Di; Zhang, Jingwen; He, Zhibin; Fedorova, Julia; Sun, Xiaodong; Han, Fang; Li, Ji.

Afiliação

Han Y; Cardiovascular Department, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, China; Department of Surgery, University of South Florida, Tampa, USA.
Sun W; Department of Surgery, University of South Florida, Tampa, USA; Cardiovascular Department, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Ren D; Department of Surgery, University of South Florida, Tampa, USA.
Zhang J; Department of Surgery, University of South Florida, Tampa, USA.
He Z; Department of Surgery, University of South Florida, Tampa, USA.
Fedorova J; Department of Surgery, University of South Florida, Tampa, USA.
Sun X; Department of Physiology and Biophysics, Mississippi Center for Heart Research, University of Mississippi Medical Center, Jackson, USA.
Han F; Department of Physiology and Biophysics, Mississippi Center for Heart Research, University of Mississippi Medical Center, Jackson, USA.
Li J; Department of Surgery, University of South Florida, Tampa, USA. Electronic address: jili@usf.edu.

Redox Biol ; 34: 101538, 2020 07.

Article em En | MEDLINE | ID: mdl-32325423

Assuntos

Inflamassomos; Traumatismo por Reperfusão Miocárdica; Animais; Isquemia; Camundongos; Camundongos Endogâmicos C57BL; Traumatismo por Reperfusão Miocárdica/tratamento farmacológico; Traumatismo por Reperfusão Miocárdica/genética; Proteína 3 que Contém Domínio de Pirina da Família NLR/genética; Oxirredutases; Piruvatos; Reperfusão; Sirtuína 1/genética

Palavras-chave

Ischemia/reperfusion; NLRP3 inflammasome; ROS; SIRT1 agonist

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão Miocárdica / Inflamassomos Limite: Animals Idioma: En Revista: Redox Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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