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The role of dietary antioxidant index and index of nutritional quality in MS onset: finding from an Iranian population-based incident case-control study.
Abdollahpour, Ibrahim; Nedjat, Saharnaz; Salimi, Yahya; Mansournia, Mohammad Ali; Vahid, Farhad; Weinstock-Guttman, Bianca.
Afiliação
  • Abdollahpour I; Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Nedjat S; Department of Epidemiology and Biostatistics, School of Public Health, Knowledge Utilization Research Center, Tehran University of Medical Science, Tehran, Iran.
  • Salimi Y; Social Development and Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Mansournia MA; Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Vahid F; Department of Nutritional Sciences, School of Health, Arak University of Medical Sciences, Arak, Iran.
  • Weinstock-Guttman B; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
Nutr Neurosci ; 25(2): 379-386, 2022 Feb.
Article em En | MEDLINE | ID: mdl-32336221
METHODS: This was a large population-based case-control study recruiting 547 incident cases and 1057 population controls between August 2013 and February 2015. DAI and INQ were calculated based on the adolescence dietary intake of the participants. Logistic regression was employed for estimating adjusted odds ratios (OR) and their 95% confidence interval in 2018. RESULTS: Participants with less than median DAI values had two-fold increased risk of MS onset (adjusted OR 2.05, 95% CI: 1.64-2.58, P < 0.001). A significant dose-response pattern for DAI (adjusted OR 1.35, 95% CI: 1.18-1.55, P for trend <0.001) was also detected. In the case of INQ, the strongest decreased risk were detected for vitamin D (OR = 0.09) and Zinc (OR = 0.34), followed by vitamin A (OR = 0.49), Calcium (OR = 0.49) and vitamin B6 (OR = 0.51) (All P-values < 0.05). CONCLUSION: Considering the inherent limitation of case-control designs, an appropriate intake of nutrient antioxidants may have a role in decreasing the likelihood of MS risk. Moreover, those with healthier diet assessed by index of nutritional quality were at decreased risk for MS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dieta / Antioxidantes Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Humans País/Região como assunto: Asia Idioma: En Revista: Nutr Neurosci Assunto da revista: CIENCIAS DA NUTRICAO / NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Irã

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dieta / Antioxidantes Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Humans País/Região como assunto: Asia Idioma: En Revista: Nutr Neurosci Assunto da revista: CIENCIAS DA NUTRICAO / NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Irã