New phenylspirodrimane metabolites MBJ-0030, MBJ-0031, and MBJ-0032 isolated from the soil fungal strain <i>Stachybotrys</i> sp. f23793.

Kawahara, Teppei; Itoh, Masashi; Izumikawa, Miho; Kagaya, Noritaka; Sakata, Noriaki; Tsuchida, Toshio; Shin-Ya, Kazuo

New phenylspirodrimane metabolites MBJ-0030, MBJ-0031, and MBJ-0032 isolated from the soil fungal strain Stachybotrys sp. f23793.

Kawahara, Teppei; Itoh, Masashi; Izumikawa, Miho; Kagaya, Noritaka; Sakata, Noriaki; Tsuchida, Toshio; Shin-Ya, Kazuo.

Afiliação

Kawahara T; Japan Biological Informatics Consortium (JBIC) , Tokyo, Japan.
Itoh M; Research & Development Division, MicroBiopharm Japan Co., Ltd (MBJ) , Iwata, Japan.
Izumikawa M; Japan Biological Informatics Consortium (JBIC) , Tokyo, Japan.
Kagaya N; National Institute of Advanced Industrial Science and Technology (AIST) , Tokyo, Japan.
Sakata N; Research & Development Division, MicroBiopharm Japan Co., Ltd (MBJ) , Iwata, Japan.
Tsuchida T; Research & Development Division, MicroBiopharm Japan Co., Ltd (MBJ) , Iwata, Japan.
Shin-Ya K; National Institute of Advanced Industrial Science and Technology (AIST) , Tokyo, Japan.

Biosci Biotechnol Biochem ; 84(8): 1570-1575, 2020 Aug.

Article em En | MEDLINE | ID: mdl-32338185

ABSTRACT

ABSTRACT

Chemical screening of culture medium from the soil fungus Stachybotrys sp. resulted in the isolation of the three new phenylspirodrimanes MBJ-0030 (1), MBJ-0031 (2) and MBJ-0032 (3). Their structures were determined by detailed analysis of spectroscopic data. The absolute configurations of 1-3 were determined by modified Mosher's and Marfey's methods. In addition, cytotoxic and antimicrobial evaluations of the compounds were conducted.

Assuntos

Sesquiterpenos Policíclicos/química; Compostos de Espiro/química; Stachybotrys/química; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Humanos; Micrococcus luteus/efeitos dos fármacos; Micrococcus luteus/crescimento & desenvolvimento; Sesquiterpenos Policíclicos/isolamento & purificação; Microbiologia do Solo; Compostos de Espiro/isolamento & purificação; Stachybotrys/isolamento & purificação

Palavras-chave

Stachybotrys; phenylspirodrimane; stachybotrin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Stachybotrys / Sesquiterpenos Policíclicos Limite: Humans Idioma: En Revista: Biosci Biotechnol Biochem Assunto da revista: BIOQUIMICA / BIOTECNOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão

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