Transcriptomic and proteomic profiling of glial versus neuronal Dube3a overexpression reveals common molecular changes in gliopathic epilepsies.

Hope, Kevin A; Johnson, Daniel; Miller, P Winston; Lopez-Ferrer, Daniel; Kakhniashvili, David; Reiter, Lawrence T

Hope, Kevin A; Johnson, Daniel; Miller, P Winston; Lopez-Ferrer, Daniel; Kakhniashvili, David; Reiter, Lawrence T.

Afiliação

Hope KA; Department of Neurology, UTHSC, Memphis, TN, United States of America; Integrated Biomedical Science Program, UTHSC, Memphis, TN, United States of America. Electronic address: khope@genetics.utah.edu.
Johnson D; Molecular Bioinformatics Core, UTHSC, Memphis, TN, United States of America.
Miller PW; Molecular Bioinformatics Core, UTHSC, Memphis, TN, United States of America.
Lopez-Ferrer D; Thermo Fisher Scientific, UTHSC, 180 Oyster Point Blvd, South San Francisco, CA, United States of America.
Kakhniashvili D; Proteomics and Metabolomics Core, UTHSC, Memphis, TN, United States of America.
Reiter LT; Department of Neurology, UTHSC, Memphis, TN, United States of America; Department of Pediatrics, UTHSC, Memphis, TN, United States of America; Department of Anatomy and Neurobiology, UTHSC, Memphis, TN, United States of America. Electronic address: lreiter@uthsc.edu.

Neurobiol Dis ; 141: 104879, 2020 07.

Article em En | MEDLINE | ID: mdl-32344153

Assuntos

Proteínas de Drosophila/metabolismo; Epilepsia/metabolismo; Neuroglia/metabolismo; Neurônios/metabolismo; Ubiquitina-Proteína Ligases/metabolismo; Animais; Cromossomos Humanos Par 15/metabolismo; Modelos Animais de Doenças; Drosophila melanogaster; Perfilação da Expressão Gênica; Humanos; Proteoma; Proteômica; Transcriptoma; Trissomia

Palavras-chave

Drosophila; Dup15q; Epilepsy; Glia; Gliopathic; Glutathione S-transferase; Seizure

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neuroglia / Proteínas de Drosophila / Ubiquitina-Proteína Ligases / Epilepsia / Neurônios Limite: Animals / Humans Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article

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