Inhibition of Phosphatidylinositol 3-Kinase Î³ by IPI-549 Attenuates Abdominal Aortic Aneurysm Formation in Mice.

Liu, Rui; Huang, Jianhua; Ge, Yingbin; Liu, Shuai; Huang, Tingting; Cai, Huoying; Pan, Baihong; Zhang, Qi; Yang, Pu; Liao, Mingmei; Xu, Baohui; Wang, Wei

Liu, Rui; Huang, Jianhua; Ge, Yingbin; Liu, Shuai; Huang, Tingting; Cai, Huoying; Pan, Baihong; Zhang, Qi; Yang, Pu; Liao, Mingmei; Xu, Baohui; Wang, Wei.

Afiliação

Liu R; Department of General &Vascular Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Huang J; Department of General &Vascular Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ge Y; Department of Physiology, Nanjing Medical University, Jiangning District, Nanjing, China.
Liu S; Department of General &Vascular Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Huang T; Department of General &Vascular Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Cai H; Department of General &Vascular Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Pan B; Department of General &Vascular Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhang Q; Department of General &Vascular Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yang P; Department of General &Vascular Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Liao M; Department of General &Vascular Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xu B; Department of Vascular Surgery, Stanford University School of Medicine, Stanford, USA.
Wang W; Department of General &Vascular Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: wangweicsu@126.com.

Eur J Vasc Endovasc Surg ; 60(2): 254-263, 2020 Aug.

Article em En | MEDLINE | ID: mdl-32423743

Assuntos

Aorta Abdominal/efeitos dos fármacos; Aneurisma da Aorta Abdominal/prevenção & controle; Classe Ib de Fosfatidilinositol 3-Quinase/metabolismo; Isoquinolinas/farmacologia; Inibidores de Proteínas Quinases/farmacologia; Pirazóis/farmacologia; Pirimidinas/farmacologia; Idoso; Animais; Aorta Abdominal/enzimologia; Aorta Abdominal/patologia; Aneurisma da Aorta Abdominal/enzimologia; Aneurisma da Aorta Abdominal/patologia; Estudos de Casos e Controles; Modelos Animais de Doenças; Feminino; Humanos; Isoquinolinas/uso terapêutico; Macrófagos/efeitos dos fármacos; Macrófagos/enzimologia; Masculino; Camundongos Endogâmicos C57BL; Pessoa de Meia-Idade; Fosforilação; Proteínas Proto-Oncogênicas c-akt/metabolismo; Pirazóis/uso terapêutico; Pirimidinas/uso terapêutico; Linfócitos T/efeitos dos fármacos; Linfócitos T/enzimologia

Palavras-chave

AKT; Abdominal aortic aneurysm; Experimental animal models; Inflammation; Lymphocytes; Macrophages; Phosphatidylinositol 3-kinase Î³

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta Abdominal / Pirazóis / Pirimidinas / Aneurisma da Aorta Abdominal / Inibidores de Proteínas Quinases / Classe Ib de Fosfatidilinositol 3-Quinase / Isoquinolinas Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Vasc Endovasc Surg Assunto da revista: ANGIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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