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Elasticizing tissues for reversible shape transformation and accelerated molecular labeling.
Ku, Taeyun; Guan, Webster; Evans, Nicholas B; Sohn, Chang Ho; Albanese, Alexandre; Kim, Joon-Goon; Frosch, Matthew P; Chung, Kwanghun.
Afiliação
  • Ku T; Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
  • Guan W; Picower Institute for Learning and Memory, MIT, Cambridge, MA, USA.
  • Evans NB; Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea.
  • Sohn CH; Department of Chemical Engineering, MIT, Cambridge, MA, USA.
  • Albanese A; Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
  • Kim JG; Picower Institute for Learning and Memory, MIT, Cambridge, MA, USA.
  • Frosch MP; Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
  • Chung K; Picower Institute for Learning and Memory, MIT, Cambridge, MA, USA.
Nat Methods ; 17(6): 609-613, 2020 06.
Article em En | MEDLINE | ID: mdl-32424271
ABSTRACT
We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Coloração e Rotulagem / Hidrogéis / Engenharia Tecidual Limite: Animals / Humans Idioma: En Revista: Nat Methods Assunto da revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Coloração e Rotulagem / Hidrogéis / Engenharia Tecidual Limite: Animals / Humans Idioma: En Revista: Nat Methods Assunto da revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos