Design, synthesis and antitrypanosomal activity of heteroaryl-based 1,2,4-triazole and 1,3,4-oxadiazole derivatives.

Shaykoon, Montaser Sh; Marzouk, Adel A; Soltan, Osama M; Wanas, Amira S; Radwan, Mohamed M; Gouda, Ahmed M; Youssif, Bahaa G M; Abdel-Aziz, Mohamed

Shaykoon, Montaser Sh; Marzouk, Adel A; Soltan, Osama M; Wanas, Amira S; Radwan, Mohamed M; Gouda, Ahmed M; Youssif, Bahaa G M; Abdel-Aziz, Mohamed.

Afiliação

Shaykoon MS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Marzouk AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Soltan OM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Wanas AS; National Center for Natural Products Research, University of Mississippi, MS 38677, USA; Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
Radwan MM; National Center for Natural Products Research, University of Mississippi, MS 38677, USA.
Gouda AM; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Youssif BGM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: bgyoussif@ju.edu.sa.
Abdel-Aziz M; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt. Electronic address: Abulnil@hotmail.com.

Bioorg Chem ; 100: 103933, 2020 07.

Article em En | MEDLINE | ID: mdl-32446119

Assuntos

Antiprotozoários/síntese química; Desenho de Fármacos; Oxidiazóis/química; Triazóis/química; Antiprotozoários/metabolismo; Antiprotozoários/farmacologia; Sítios de Ligação; Simulação de Acoplamento Molecular; Oxidiazóis/metabolismo; Oxidiazóis/farmacologia; Proteínas de Protozoários/química; Proteínas de Protozoários/metabolismo; Esterol 14-Desmetilase/química; Esterol 14-Desmetilase/metabolismo; Relação Estrutura-Atividade; Triazóis/metabolismo; Triazóis/farmacologia; Trypanosoma brucei brucei/efeitos dos fármacos

Palavras-chave

1,2,4-triazole; 1,3,4-oxadiazole; Antitrypanosomal; Docking; Pyrazine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxidiazóis / Triazóis / Desenho de Fármacos / Antiprotozoários Tipo de estudo: Prognostic_studies Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Egito

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