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Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer.
Chopra, Neha; Tovey, Holly; Pearson, Alex; Cutts, Ros; Toms, Christy; Proszek, Paula; Hubank, Michael; Dowsett, Mitch; Dodson, Andrew; Daley, Frances; Kriplani, Divya; Gevensleben, Heidi; Davies, Helen Ruth; Degasperi, Andrea; Roylance, Rebecca; Chan, Stephen; Tutt, Andrew; Skene, Anthony; Evans, Abigail; Bliss, Judith M; Nik-Zainal, Serena; Turner, Nicholas C.
Afiliação
  • Chopra N; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, CB2 0XZ, United Kingdom.
  • Tovey H; Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, United Kingdom.
  • Pearson A; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, CB2 0XZ, United Kingdom.
  • Cutts R; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, CB2 0XZ, United Kingdom.
  • Toms C; Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, United Kingdom.
  • Proszek P; The Centre for Molecular Pathology, The Royal Marsden Hospital, 15 Cotswold Road, Sutton, SM2 5NG, Surrey, United Kingdom.
  • Hubank M; The Centre for Molecular Pathology, The Royal Marsden Hospital, 15 Cotswold Road, Sutton, SM2 5NG, Surrey, United Kingdom.
  • Dowsett M; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, CB2 0XZ, United Kingdom.
  • Dodson A; Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital, London, United Kingdom.
  • Daley F; Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital, London, United Kingdom.
  • Kriplani D; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, CB2 0XZ, United Kingdom.
  • Gevensleben H; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, CB2 0XZ, United Kingdom.
  • Davies HR; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, CB2 0XZ, United Kingdom.
  • Degasperi A; Department of Medical Genetics, The Clinical School, Box 238, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, United Kingdom.
  • Roylance R; MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, United Kingdom.
  • Chan S; Department of Medical Genetics, The Clinical School, Box 238, Level 6 Addenbrooke's Treatment Centre, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, United Kingdom.
  • Tutt A; MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, United Kingdom.
  • Skene A; University College London Hospitals NHS Foundation Trust, NIHR University College London Hospitals Biomedical Research Centre, London, United Kingdom.
  • Evans A; Nottingham University Hospital Trust (City Campus), Nottingham, United Kingdom.
  • Bliss JM; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, CB2 0XZ, United Kingdom.
  • Nik-Zainal S; Breast Cancer Now Research Unit, Cancer Centre, Guy's Hospital, King's College London, London, United Kingdom.
  • Turner NC; Royal Bournemouth Hospital, Bournemouth, United Kingdom.
Nat Commun ; 11(1): 2662, 2020 05 29.
Article em En | MEDLINE | ID: mdl-32471999
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reparo de DNA por Recombinação / Neoplasias de Mama Triplo Negativas / Inibidores de Poli(ADP-Ribose) Polimerases / Poli(ADP-Ribose) Polimerase-1 / Indóis Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reparo de DNA por Recombinação / Neoplasias de Mama Triplo Negativas / Inibidores de Poli(ADP-Ribose) Polimerases / Poli(ADP-Ribose) Polimerase-1 / Indóis Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido