All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery.
Biomater Sci
; 8(12): 3270-3277, 2020 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-32490443
ABSTRACT
Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Quitosana
/
Nanopartículas
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Hipoglicemiantes
/
Insulina
Limite:
Humans
Idioma:
En
Revista:
Biomater Sci
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Finlândia