Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13.

Liu, Yao; Hao, Mingfeng; Leggett, Alan L; Gao, Yang; Ficarro, Scott B; Che, Jianwei; He, Zhixiang; Olson, Calla M; Marto, Jarrod A; Kwiatkowski, Nicholas P; Zhang, Tinghu; Gray, Nathanael S

Liu, Yao; Hao, Mingfeng; Leggett, Alan L; Gao, Yang; Ficarro, Scott B; Che, Jianwei; He, Zhixiang; Olson, Calla M; Marto, Jarrod A; Kwiatkowski, Nicholas P; Zhang, Tinghu; Gray, Nathanael S.

Afiliação

Liu Y; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.
Hao M; Department of Cancer Biology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States.
Leggett AL; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.
Gao Y; Department of Cancer Biology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States.
Ficarro SB; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.
Che J; Department of Cancer Biology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States.
He Z; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.
Olson CM; Department of Cancer Biology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States.
Marto JA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.
Kwiatkowski NP; Department of Cancer Biology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States.
Zhang T; Blais Proteomics Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, United States.
Gray NS; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.

J Med Chem ; 63(13): 6708-6726, 2020 07 09.

Article em En | MEDLINE | ID: mdl-32502343

Assuntos

Proteína Quinase CDC2/antagonistas & inibidores; Quinases Ciclina-Dependentes/antagonistas & inibidores; Descoberta de Drogas; Inibidores de Proteínas Quinases/farmacologia; Proteína Quinase CDC2/química; Quinases Ciclina-Dependentes/química; Humanos; Células Jurkat; Modelos Moleculares; Conformação Proteica

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Quinase CDC2 / Quinases Ciclina-Dependentes / Inibidores de Proteínas Quinases / Descoberta de Drogas Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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