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Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
Álvarez-Quilón, Alejandro; Wojtaszek, Jessica L; Mathieu, Marie-Claude; Patel, Tejas; Appel, C Denise; Hustedt, Nicole; Rossi, Silvia Emma; Wallace, Bret D; Setiaputra, Dheva; Adam, Salomé; Ohashi, Yota; Melo, Henrique; Cho, Tiffany; Gervais, Christian; Muñoz, Ivan M; Grazzini, Eric; Young, Jordan T F; Rouse, John; Zinda, Michael; Williams, R Scott; Durocher, Daniel.
Afiliação
  • Álvarez-Quilón A; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
  • Wojtaszek JL; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
  • Mathieu MC; Repare Therapeutics, 7210 Frederick-Banting, Suite 100, St-Laurent, QC H4S 2A1, Canada.
  • Patel T; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
  • Appel CD; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
  • Hustedt N; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
  • Rossi SE; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
  • Wallace BD; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
  • Setiaputra D; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
  • Adam S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
  • Ohashi Y; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
  • Melo H; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.
  • Cho T; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
  • Gervais C; National Research Council Canada Human Health Therapeutics Research Center, 6100 Royalmount Avenue, Montreal, QC H4P 2R2, Canada.
  • Muñoz IM; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
  • Grazzini E; National Research Council Canada Human Health Therapeutics Research Center, 6100 Royalmount Avenue, Montreal, QC H4P 2R2, Canada.
  • Young JTF; Repare Therapeutics, 7210 Frederick-Banting, Suite 100, St-Laurent, QC H4S 2A1, Canada.
  • Rouse J; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
  • Zinda M; Repare Therapeutics, 7210 Frederick-Banting, Suite 100, St-Laurent, QC H4S 2A1, Canada.
  • Williams RS; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. Electronic address: willia
  • Durocher D; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address: durocher@lunenfeld.ca.
Mol Cell ; 78(6): 1152-1165.e8, 2020 06 18.
Article em En | MEDLINE | ID: mdl-32516598
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína BRCA1 / Proteína BRCA2 / DNA Liase (Sítios Apurínicos ou Apirimidínicos) / Endonucleases / Enzimas Multifuncionais Limite: Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína BRCA1 / Proteína BRCA2 / DNA Liase (Sítios Apurínicos ou Apirimidínicos) / Endonucleases / Enzimas Multifuncionais Limite: Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá