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Intrinsically stretchable electrode array enabled in vivo electrophysiological mapping of atrial fibrillation at cellular resolution.
Liu, Jia; Zhang, Xinyuan; Liu, Yuxin; Rodrigo, Miguel; Loftus, Patrick D; Aparicio-Valenzuela, Joy; Zheng, Jukuan; Pong, Terrence; Cyr, Kevin J; Babakhanian, Meghedi; Hasi, Jasmine; Li, Jinxing; Jiang, Yuanwen; Kenney, Christopher J; Wang, Paul J; Lee, Anson M; Bao, Zhenan.
Afiliação
  • Liu J; Department of Chemical Engineering, Stanford University, Stanford, CA 94305.
  • Zhang X; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA 94305.
  • Liu Y; Division of Cardiovascular Medicine, Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305.
  • Rodrigo M; Department of Bioengineering, Stanford University, Stanford, CA 94305.
  • Loftus PD; Division of Cardiovascular Medicine, Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305.
  • Aparicio-Valenzuela J; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA 94305.
  • Zheng J; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA 94305.
  • Pong T; Department of Chemical Engineering, Stanford University, Stanford, CA 94305.
  • Cyr KJ; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA 94305.
  • Babakhanian M; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA 94305.
  • Hasi J; Division of Cardiovascular Medicine, Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305.
  • Li J; SLAC National Accelerator Laboratory, Menlo Park, CA 94025.
  • Jiang Y; Department of Chemical Engineering, Stanford University, Stanford, CA 94305.
  • Kenney CJ; Department of Chemical Engineering, Stanford University, Stanford, CA 94305.
  • Wang PJ; SLAC National Accelerator Laboratory, Menlo Park, CA 94025.
  • Lee AM; Division of Cardiovascular Medicine, Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305.
  • Bao Z; Department of Cardiothoracic Surgery, School of Medicine, Stanford University, Stanford, CA 94305; ansonlee@stanford.edu zbao@stanford.edu.
Proc Natl Acad Sci U S A ; 117(26): 14769-14778, 2020 06 30.
Article em En | MEDLINE | ID: mdl-32541030
Electrophysiological mapping of chronic atrial fibrillation (AF) at high throughput and high resolution is critical for understanding its underlying mechanism and guiding definitive treatment such as cardiac ablation, but current electrophysiological tools are limited by either low spatial resolution or electromechanical uncoupling of the beating heart. To overcome this limitation, we herein introduce a scalable method for fabricating a tissue-like, high-density, fully elastic electrode (elastrode) array capable of achieving real-time, stable, cellular level-resolution electrophysiological mapping in vivo. Testing with acute rabbit and porcine models, the device is proven to have robust and intimate tissue coupling while maintaining its chemical, mechanical, and electrical properties during the cardiac cycle. The elastrode array records epicardial atrial signals with comparable efficacy to currently available endocardial-mapping techniques but with 2 times higher atrial-to-ventricular signal ratio and >100 times higher spatial resolution and can reliably identify electrical local heterogeneity within an area of simultaneously identified rotor-like electrical patterns in a porcine model of chronic AF.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Técnicas Eletrofisiológicas Cardíacas / Átrios do Coração Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Técnicas Eletrofisiológicas Cardíacas / Átrios do Coração Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article