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Long Noncoding RNAs: Molecular Modalities to Organismal Functions.
Rinn, John L; Chang, Howard Y.
Afiliação
  • Rinn JL; BioFrontiers Institute, Department of Biochemistry, University of Colorado, Boulder, Colorado 80303, USA; email: john.rinn@colorado.edu.
  • Chang HY; Center for Personal Dynamic Regulomes, Stanford University, Stanford, California 94305, USA.
Annu Rev Biochem ; 89: 283-308, 2020 06 20.
Article em En | MEDLINE | ID: mdl-32569523
We have known for decades that long noncoding RNAs (lncRNAs) can play essential functions across most forms of life. The maintenance of chromosome length requires an lncRNA (e.g., hTERC) and two lncRNAs in the ribosome that are required for protein synthesis. Thus, lncRNAs can represent powerful RNA machines. More recently, it has become clear that mammalian genomes encode thousands more lncRNAs. Thus, we raise the question: Which, if any, of these lncRNAs could also represent RNA-based machines? Here we synthesize studies that are beginning to address this question by investigating fundamental properties of lncRNA genes, revealing new insights into the RNA structure-function relationship, determining cis- and trans-acting lncRNAs in vivo, and generating new developments in high-throughput screening used to identify functional lncRNAs. Overall, these findings provide a context toward understanding the molecular grammar underlying lncRNA biology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biossíntese de Proteínas / RNA / RNA Mensageiro / Genoma / Telomerase / RNA Longo não Codificante Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Annu Rev Biochem Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biossíntese de Proteínas / RNA / RNA Mensageiro / Genoma / Telomerase / RNA Longo não Codificante Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Annu Rev Biochem Ano de publicação: 2020 Tipo de documento: Article