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X-Chromosome Inactivation during Preimplantation Development and in Pluripotent Stem Cells.
Cytogenet Genome Res ; 160(6): 283-294, 2020.
Article em En | MEDLINE | ID: mdl-32575101
ABSTRACT
X dosage compensation between XX female and XY male mammalian cells is achieved by a process known as X-chromosome inactivation (XCI). XCI initiates early during preimplantation development in female cells, and it is subsequently stably maintained in somatic cells. However, XCI is a reversible process that occurs in vivo in the inner cell mass of the blastocyst, in primordial germ cells or in spermatids during reprogramming. Erasure of transcriptional gene silencing can occur though a mechanism named X-chromosome reactivation (XCR). XCI and XCR have been substantially deciphered in the mouse, whereas they still remain debated in the human. In this review, we summarized the recent advances in the knowledge of X-linked gene dosage compensation during mouse and human preimplantation development and in pluripotent stem cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes / Desenvolvimento Embrionário / Inativação do Cromossomo X Limite: Animals / Humans Idioma: En Revista: Cytogenet Genome Res Assunto da revista: GENETICA Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes / Desenvolvimento Embrionário / Inativação do Cromossomo X Limite: Animals / Humans Idioma: En Revista: Cytogenet Genome Res Assunto da revista: GENETICA Ano de publicação: 2020 Tipo de documento: Article