Non-Diazo C-H Insertion Approach to Cyclobutanones through Oxidative Gold Catalysis.
Angew Chem Int Ed Engl
; 59(40): 17398-17402, 2020 09 28.
Article
em En
| MEDLINE
| ID: mdl-32585076
ABSTRACT
Cyclobutanones are synthetically versatile compounds that often require extensive effort to access. Herein, we report a facile synthesis of cyclobutanones based on the C(sp3 )-H insertion chemistry of oxidatively generated gold carbenes. Various cyclobutanones were obtained in synthetically useful yields from substrates with minimal structural prefunctionalization. This discovery reveals new synthetic utilities of gold-catalyzed oxidative transformations of alkynones.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclobutanos
/
Ouro
/
Cetonas
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos