The PARP inhibitor, olaparib, depletes the ovarian reserve in mice: implications for fertility preservation.

Winship, Amy L; Griffiths, Meaghan; Lliberos Requesens, Carolina; Sarma, Urooza; Phillips, Kelly-Anne; Hutt, Karla J

Winship, Amy L; Griffiths, Meaghan; Lliberos Requesens, Carolina; Sarma, Urooza; Phillips, Kelly-Anne; Hutt, Karla J.

Afiliação

Winship AL; Ovarian Biology Laboratory, Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Stem Cells and Development Program, Monash University, Clayton, VIC 3800, Australia.
Griffiths M; Ovarian Biology Laboratory, Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Stem Cells and Development Program, Monash University, Clayton, VIC 3800, Australia.
Lliberos Requesens C; Ovarian Biology Laboratory, Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Stem Cells and Development Program, Monash University, Clayton, VIC 3800, Australia.
Sarma U; Ovarian Biology Laboratory, Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Stem Cells and Development Program, Monash University, Clayton, VIC 3800, Australia.
Phillips KA; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Hutt KJ; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australia.

Hum Reprod ; 35(8): 1864-1874, 2020 08 01.

Article em En | MEDLINE | ID: mdl-32604417

Assuntos

Preservação da Fertilidade; Reserva Ovariana; Adulto; Animais; Austrália; Feminino; Humanos; Camundongos; Ftalazinas; Piperazinas; Inibidores de Poli(ADP-Ribose) Polimerases/farmacologia

Palavras-chave

BRCA1; BRCA2; DNA repair; PARP; fertility; olaparib; oocyte; primordial

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preservação da Fertilidade / Reserva Ovariana Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Animals / Female / Humans País/Região como assunto: Oceania Idioma: En Revista: Hum Reprod Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália

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