Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to &#916;FosB homodimers and &#916;FosB/JunD heterodimers.

Li, Yi; Liu, Zhiqing; Aglyamova, Galina; Chen, Jianping; Chen, Haiying; Bhandari, Mukund; White, Mark A; Rudenko, Gabrielle; Zhou, Jia

Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ΔFosB homodimers and ΔFosB/JunD heterodimers.

Li, Yi; Liu, Zhiqing; Aglyamova, Galina; Chen, Jianping; Chen, Haiying; Bhandari, Mukund; White, Mark A; Rudenko, Gabrielle; Zhou, Jia.

Afiliação

Li Y; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States.
Liu Z; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States.
Aglyamova G; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States.
Chen J; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States.
Chen H; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States.
Bhandari M; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States.
White MA; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, United States; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, United States.
Rudenko G; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, United States. Electronic address: garudenk@utmb.edu.
Zhou J; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, United States. Electronic address: jizhou@utmb.edu.

Bioorg Med Chem Lett ; 30(16): 127300, 2020 08 15.

Article em En | MEDLINE | ID: mdl-32631520

Assuntos

DNA/efeitos dos fármacos; Descoberta de Drogas; Fenantridinas/farmacologia; Proteínas Proto-Oncogênicas c-fos/antagonistas & inibidores; Proteínas Proto-Oncogênicas c-jun/antagonistas & inibidores; Sítios de Ligação/efeitos dos fármacos; DNA/química; Relação Dose-Resposta a Droga; Humanos; Simulação de Acoplamento Molecular; Estrutura Molecular; Fenantridinas/química; Proteínas Proto-Oncogênicas c-fos/química; Proteínas Proto-Oncogênicas c-jun/química; Relação Estrutura-Atividade

Palavras-chave

Chemical probes; Fluorescence polarization assay; High-throughput screening; ΔFosB homodimer; ΔFosB/JunD heterodimer

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenantridinas / DNA / Proteínas Proto-Oncogênicas c-jun / Proteínas Proto-Oncogênicas c-fos / Descoberta de Drogas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google