Single-and repeat-dose toxicity of HM10760A, a long-acting erythropoietin, in rats and monkeys.

Lim, Hyung-Kyu; Choi, Jaehyuk; Kim, Daejin; Bae, Sung Min; Kim, Dae Kyong; Choi, In Young; Kim, Ha Hyung

Lim, Hyung-Kyu; Choi, Jaehyuk; Kim, Daejin; Bae, Sung Min; Kim, Dae Kyong; Choi, In Young; Kim, Ha Hyung.

Afiliação

Lim HK; Biotherapeutics and Glycomics Laboratory, College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea; Hanmi Research Center, Hanmi Pharm. Co. Ltd., 550 Dongtangiheung-Ro, Hwaseong-Si, Gyeonggi-Do 18469, Republic of Korea.
Choi J; Biotherapeutics and Glycomics Laboratory, College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea; Hanmi Research Center, Hanmi Pharm. Co. Ltd., 550 Dongtangiheung-Ro, Hwaseong-Si, Gyeonggi-Do 18469, Republic of Korea.
Kim D; Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea; Hanmi Research Center, Hanmi Pharm. Co. Ltd., 550 Dongtangiheung-Ro, Hwaseong-Si, Gyeonggi-Do 18469, Republic of Korea.
Bae SM; Hanmi Research Center, Hanmi Pharm. Co. Ltd., 550 Dongtangiheung-Ro, Hwaseong-Si, Gyeonggi-Do 18469, Republic of Korea.
Kim DK; Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea. Electronic address: kimdk@cau.ac.kr.
Choi IY; Hanmi Research Center, Hanmi Pharm. Co. Ltd., 550 Dongtangiheung-Ro, Hwaseong-Si, Gyeonggi-Do 18469, Republic of Korea. Electronic address: iychoi@hanmi.co.kr.
Kim HH; Biotherapeutics and Glycomics Laboratory, College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea. Electronic address: hahyung@cau.ac.kr.

Toxicol Appl Pharmacol ; 402: 115126, 2020 09 01.

Article em En | MEDLINE | ID: mdl-32645313

Assuntos

Eritropoetina/análogos & derivados; Eritropoetina/farmacologia; Animais; Relação Dose-Resposta a Droga; Esquema de Medicação; Eritropoetina/administração & dosagem; Eritropoetina/efeitos adversos; Macaca fascicularis; Ratos; Ratos Sprague-Dawley

Palavras-chave

Chronic kidney disease; HM10760A; Long-acting erythropoietin; NOAEL; Toxicity

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Eritropoetina Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google