Inhibiting DNA Methylation Improves Survival in Severe Sepsis by Regulating NF-&#954;B Pathway.

Cao, Luxi; Zhu, Tingting; Lang, Xiabing; Jia, Sha; Yang, Yi; Zhu, Chaohong; Wang, Yucheng; Feng, Shi; Wang, Cuili; Zhang, Ping; Chen, Jianghua; Jiang, Hong

Inhibiting DNA Methylation Improves Survival in Severe Sepsis by Regulating NF-κB Pathway.

Cao, Luxi; Zhu, Tingting; Lang, Xiabing; Jia, Sha; Yang, Yi; Zhu, Chaohong; Wang, Yucheng; Feng, Shi; Wang, Cuili; Zhang, Ping; Chen, Jianghua; Jiang, Hong.

Afiliação

Cao L; Kidney Disease Center, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Zhu T; Key Laboratory of Nephropathy, Hangzhou, China.
Lang X; Kidney Disease Immunology Laboratory, The Third-Grade Laboratory, State Administration of Traditional Chinese Medicine of China, Beijing, China.
Jia S; Key Laboratory of Multiple Organ Transplantation, Ministry of Health of China, Hangzhou, China.
Yang Y; Institute of Nephropathy, Zhejiang University, Hangzhou, China.
Zhu C; Kidney Disease Center, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Wang Y; Key Laboratory of Nephropathy, Hangzhou, China.
Feng S; Kidney Disease Immunology Laboratory, The Third-Grade Laboratory, State Administration of Traditional Chinese Medicine of China, Beijing, China.
Wang C; Key Laboratory of Multiple Organ Transplantation, Ministry of Health of China, Hangzhou, China.
Zhang P; Institute of Nephropathy, Zhejiang University, Hangzhou, China.
Chen J; Kidney Disease Center, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Jiang H; Key Laboratory of Nephropathy, Hangzhou, China.

Front Immunol ; 11: 1360, 2020.

Article em En | MEDLINE | ID: mdl-32714333

Assuntos

Metilação de DNA/fisiologia; Decitabina/farmacologia; Inibidores Enzimáticos/farmacologia; NF-kappa B/metabolismo; Sepse/metabolismo; Animais; Metilação de DNA/efeitos dos fármacos; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/fisiologia

Palavras-chave

CLP; DNA methylation; DNMTs; NF-κB pathway; inflammatory cytokine; sepsis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Sepse / Metilação de DNA / Inibidores Enzimáticos / Decitabina Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Front Immunol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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