Driving Protein Conformational Cycles in Physiology and Disease: "Frustrated" Amino Acid Interaction Networks Define Dynamic Energy Landscapes: Amino Acid Interaction Networks Change Progressively Along Alpha Tryptophan Synthase's Catalytic Cycle.

D'Amico, Rebecca N; Murray, Alec M; Boehr, David D

D'Amico, Rebecca N; Murray, Alec M; Boehr, David D.

Afiliação

D'Amico RN; Department of Chemistry, The Pennsylvania State University, 107 Chemistry Building, University Park, PA, 16802, USA.
Murray AM; Department of Chemistry, The Pennsylvania State University, 107 Chemistry Building, University Park, PA, 16802, USA.
Boehr DD; Department of Chemistry, The Pennsylvania State University, 107 Chemistry Building, University Park, PA, 16802, USA.

Bioessays ; 42(9): e2000092, 2020 09.

Article em En | MEDLINE | ID: mdl-32720327

Assuntos

Triptofano Sintase; Regulação Alostérica; Aminoácidos; Catálise; Conformação Proteica; Triptofano; Triptofano Sintase/metabolismo

Palavras-chave

allosteric network; allostery; catalytic cycle; conformational dynamics; energy landscape; molecular evolution; nuclear magnetic resonance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triptofano Sintase Idioma: En Revista: Bioessays Assunto da revista: BIOLOGIA / BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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