Structure-activity relationships in the beta-lactam family: an impossible dream.
Biochem Pharmacol
; 37(1): 125-32, 1988 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-3276315
ABSTRACT
The difficulty of establishing structure-activity relationships in the beta-lactam family of antibiotics stems from the fact that (1) The targets in various bacteria exhibit widely different sensitivities. (2) Some bacteria produce beta-lactamases, enzymes capable of destroying the antibiotics. The rates of the reactions with the beta-lactamases and the target enzymes are not necessarily related. (3) In Gram-negative bacteria, the diffusion rate through the outer membrane varies independently from the two other factors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antibacterianos
Idioma:
En
Revista:
Biochem Pharmacol
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Bélgica