A Novel Compound Sclerosant: Polidocanol-Bleomycin Foam.
Dermatol Surg
; 46(12): 1712-1714, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-32769523
ABSTRACT
BACKGROUND:
Foam sclerotherapy is an effective treatment strategy for venous malformations. Both polidocanol (POL) and bleomycin are effective sclerosants; however, no studies have reported POL-bleomycin foam.OBJECTIVE:
To introduce a method for producing POL-bleomycin foam and evaluate the stability of POL-bleomycin foam with bleomycin concentrations. MATERIALS ANDMETHODS:
Group A 2 mL of 1% POL + 8 mL of air; Group B 2 mL of 1% POL + 3 U bleomycin + 8 mL of air; Group C 2 mL of 1% POL + 6 U bleomycin + 8 mL of air; Group D 2 mL of 1% POL + 12 U bleomycin + 8 mL of air. Tessari method was used for foam generation. The foam half-life time (FHT) was used to evaluate foam stability. Five recordings were made for each group.RESULTS:
The FHT was 148.6 ± 2.9 seconds in Group A, 148.8 ± 4.0 seconds in Group B, 148.4 ± 2.6 seconds in Group C, and 148.8 ± 1.6 seconds in Group D. The FHT in different groups showed no significant differences.CONCLUSION:
The POL-bleomycin foam was prepared successfully and its FHT was as long as the POL foam.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Soluções Esclerosantes
/
Bleomicina
/
Composição de Medicamentos
/
Malformações Vasculares
/
Polidocanol
Limite:
Humans
Idioma:
En
Revista:
Dermatol Surg
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China