Crystallization of human c-H-ras oncogene products.
J Mol Biol
; 200(1): 205-7, 1988 Mar 05.
Article
em En
| MEDLINE
| ID: mdl-3288757
ABSTRACT
There is compelling evidence that cancer develops as a consequence of genetic changes (probably multiple) in some members of a selected set of cellular genes. DNA isolated from a variety of tumors, but not normal tissues, possesses the ability to malignantly transform non-tumorigenic cells. Many oncogenes responsible for such transformation have been isolated from transformed cell lines and animal and human tumors induced spontaneously, by virus, by chemical, or by radiation. The most commonly found transforming genes isolated from human tumor cells by DNA transfection assay are the ras gene family (c-H-ras, c-K-ras and N-ras). We report crystallization of several human c-H-ras oncogene proteins.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Proto-Oncogênicas
Limite:
Humans
Idioma:
En
Revista:
J Mol Biol
Ano de publicação:
1988
Tipo de documento:
Article