Effect of Withania somnifera (L.) Dunal aqueous root extract on reinstatement using conditioned place preference and brain GABA and dopamine levels in alcohol dependent animals.

Marathe, P A; Satam, S D; Raut, S B; Shetty, Y C; Pooja, S G; Raut, A A; Kale, P P; Rege, N N

Marathe, P A; Satam, S D; Raut, S B; Shetty, Y C; Pooja, S G; Raut, A A; Kale, P P; Rege, N N.

Afiliação

Marathe PA; Department of Pharmacology & Therapeutics, Seth Gordhandas Sundardas Medical College & King Edward Memorial Hospital, Parel, Mumbai, 400 012, India.
Satam SD; Department of Pharmacology & Therapeutics, Seth Gordhandas Sundardas Medical College & King Edward Memorial Hospital, Parel, Mumbai, 400 012, India.
Raut SB; School of Psychological Sciences, College of Health and Medicine, University of Tasmania, Launceston, 7250, Australia.
Shetty YC; Department of Pharmacology & Therapeutics, Seth Gordhandas Sundardas Medical College & King Edward Memorial Hospital, Parel, Mumbai, 400 012, India. Electronic address: yshetty2020@gmail.com.
Pooja SG; Department of Pharmacology & Therapeutics, Seth Gordhandas Sundardas Medical College & King Edward Memorial Hospital, Parel, Mumbai, 400 012, India.
Raut AA; Medical Research Centre of Kasturba Health Society, Vile Parle (west), Mumbai, India.
Kale PP; SVKMs Dr Bhanuben Nanavati College of Pharmacy, Vile Parle, Mumbai, India.
Rege NN; Department of Pharmacology & Therapeutics, Seth Gordhandas Sundardas Medical College & King Edward Memorial Hospital, Parel, Mumbai, 400 012, India.

J Ethnopharmacol ; 274: 113304, 2021 Jun 28.

Article em En | MEDLINE | ID: mdl-32920131

Assuntos

Alcoolismo/tratamento farmacológico; Dopamina/metabolismo; Extratos Vegetais/farmacologia; Raízes de Plantas/química; Withania/química; Ácido gama-Aminobutírico/metabolismo; Alcoolismo/metabolismo; Animais; Comportamento Animal/efeitos dos fármacos; Encéfalo/efeitos dos fármacos; Encéfalo/metabolismo; Modelos Animais de Doenças; Feminino; Masculino; Ayurveda; Camundongos; Naltrexona/farmacologia; Naltrexona/uso terapêutico; Extratos Vegetais/uso terapêutico; Ratos Wistar

Palavras-chave

Alcohol use disorder; Ayurveda; GABA; Reinstatement; Reward pathway; Withania somnifera (L.) Dunal

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Dopamina / Raízes de Plantas / Withania / Alcoolismo / Ácido gama-Aminobutírico Limite: Animals Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia

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