Human papillomavirus 16 (HPV 16) E6 but not E7 inhibits the antitumor activity of LKB1 in lung cancer cells by downregulating the expression of KIF7.

Hu, Yue; Wu, Ming-Zhe; Gu, Na-Jin; Xu, Hong-Tao; Li, Qing-Chang; Wu, Guang-Ping

Hu, Yue; Wu, Ming-Zhe; Gu, Na-Jin; Xu, Hong-Tao; Li, Qing-Chang; Wu, Guang-Ping.

Afiliação

Hu Y; Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.
Wu MZ; Department of Pathology, First Hospital of Qinhuangdao, Qinhuangdao, China.
Gu NJ; Departments of Gynecology, The First Hospital of China Medical University, Shenyang, China.
Xu HT; Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.
Li QC; Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.
Wu GP; Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.

Thorac Cancer ; 11(11): 3175-3180, 2020 11.

Article em En | MEDLINE | ID: mdl-32945133

Assuntos

Papillomavirus Humano 16/metabolismo; Cinesinas/biossíntese; Neoplasias Pulmonares/metabolismo; Proteínas Oncogênicas Virais/metabolismo; Proteínas E7 de Papillomavirus/metabolismo; Proteínas Serina-Treonina Quinases/antagonistas & inibidores; Proteínas Repressoras/metabolismo; Quinases Proteína-Quinases Ativadas por AMP; Linhagem Celular Tumoral; Regulação para Baixo; Feminino; Humanos; Cinesinas/genética; Cinesinas/metabolismo; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Neoplasias Pulmonares/virologia; Masculino; Proteínas Oncogênicas Virais/genética; Proteínas E7 de Papillomavirus/genética; Proteínas Serina-Treonina Quinases/biossíntese; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/metabolismo; Proteínas Repressoras/genética; Transfecção

Palavras-chave

Human papillomavirus (HPV); kinesin family member 7 (KIF7); liver kinase B1 (LKB1); lung cancer; serine/threonine kinase 11 (STK11)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Proteínas Oncogênicas Virais / Cinesinas / Proteínas Serina-Treonina Quinases / Papillomavirus Humano 16 / Proteínas E7 de Papillomavirus / Neoplasias Pulmonares Limite: Female / Humans / Male Idioma: En Revista: Thorac Cancer Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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