The Product of Matrix Metalloproteinase Cleavage of Doxorubicin Conjugate for Anticancer Drug Delivery: Calorimetric, Spectroscopic, and Molecular Dynamics Studies on Peptide-Doxorubicin Binding to DNA.

Butowska, Kamila; Zamojc, Krzysztof; Kogut, Mateusz; Kozak, Witold; Wyrzykowski, Dariusz; Wiczk, Wieslaw; Czub, Jacek; Piosik, Jacek; Rak, Janusz

Butowska, Kamila; Zamojc, Krzysztof; Kogut, Mateusz; Kozak, Witold; Wyrzykowski, Dariusz; Wiczk, Wieslaw; Czub, Jacek; Piosik, Jacek; Rak, Janusz.

Afiliação

Butowska K; Laboratory of Biophysics, Intercollegiate Faculty of Biotechnology University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland.
Zamojc K; Department of Physical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Kogut M; Department of General and Inorganic Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Kozak W; Department of Physical Chemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gdansk, Poland.
Wyrzykowski D; Department of Physical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Wiczk W; Department of General and Inorganic Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Czub J; Department of Biomedical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.
Piosik J; Department of Physical Chemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gdansk, Poland.
Rak J; Laboratory of Biophysics, Intercollegiate Faculty of Biotechnology University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland.

Int J Mol Sci ; 21(18)2020 Sep 21.

Article em En | MEDLINE | ID: mdl-32967212

Assuntos

DNA/química; Doxorrubicina/química; Metaloproteinases da Matriz/química; Simulação de Dinâmica Molecular; Peptídeos/química; Preparações de Ação Retardada/química; Humanos

Palavras-chave

DNA; cleavable peptide; doxorubicin; drug delivery; intercalation; matrix metalloproteinases

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / DNA / Doxorrubicina / Metaloproteinases da Matriz / Simulação de Dinâmica Molecular Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Polônia

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