Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium.

Mizukoshi, Yumiko; Takeuchi, Koh; Tokunaga, Yuji; Matsuo, Hitomi; Imai, Misaki; Fujisaki, Miwa; Kamoshida, Hajime; Takizawa, Takeshi; Hanzawa, Hiroyuki; Shimada, Ichio

Mizukoshi, Yumiko; Takeuchi, Koh; Tokunaga, Yuji; Matsuo, Hitomi; Imai, Misaki; Fujisaki, Miwa; Kamoshida, Hajime; Takizawa, Takeshi; Hanzawa, Hiroyuki; Shimada, Ichio.

Afiliação

Mizukoshi Y; Japan Biological Informatics Consortium, Tokyo 135-0063, Japan.
Takeuchi K; National Institute of Advanced Industrial Science and Technology (AIST), Molecular Profiling Research Center for Drug Discovery (molprof) and Cellular and Molecular Biotechnology Research Institute, Tokyo 135-0063, Japan. koh-takeuchi@aist.go.jp ichio.shimada@riken.jp.
Tokunaga Y; National Institute of Advanced Industrial Science and Technology (AIST), Molecular Profiling Research Center for Drug Discovery (molprof) and Cellular and Molecular Biotechnology Research Institute, Tokyo 135-0063, Japan.
Matsuo H; Japan Biological Informatics Consortium, Tokyo 135-0063, Japan.
Imai M; Japan Biological Informatics Consortium, Tokyo 135-0063, Japan.
Fujisaki M; Japan Biological Informatics Consortium, Tokyo 135-0063, Japan.
Kamoshida H; Japan Biological Informatics Consortium, Tokyo 135-0063, Japan.
Takizawa T; Daiichi Sankyo RD Novare Co. Ltd., Tokyo 134-8630, Japan.
Hanzawa H; Daiichi Sankyo RD Novare Co. Ltd., Tokyo 134-8630, Japan.
Shimada I; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan. koh-takeuchi@aist.go.jp ichio.shimada@riken.jp.

Sci Adv ; 6(40)2020 09.

Article em En | MEDLINE | ID: mdl-32998885

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Sci Adv Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão

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