Therapeutic Potential of (-)-Agelamide D, a Diterpene Alkaloid from the Marine Sponge <i>Agelas</i> sp., as a Natural Radiosensitizer in Hepatocellular Carcinoma Models.

Choi, Changhoon; Cho, Yeonwoo; Son, Arang; Shin, Sung-Won; Lee, Yeon-Ju; Park, Hee Chul

Therapeutic Potential of (-)-Agelamide D, a Diterpene Alkaloid from the Marine Sponge Agelas sp., as a Natural Radiosensitizer in Hepatocellular Carcinoma Models.

Choi, Changhoon; Cho, Yeonwoo; Son, Arang; Shin, Sung-Won; Lee, Yeon-Ju; Park, Hee Chul.

Afiliação

Choi C; Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Korea.
Cho Y; Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyangro, Busan 49111, Korea.
Son A; Department of Applied Ocean Science, University of Science and Technology, Daejeon 34113, Korea.
Shin SW; Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Korea.
Lee YJ; Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Korea.
Park HC; Department of Radiation Oncology, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Mar Drugs ; 18(10)2020 Sep 29.

Article em En | MEDLINE | ID: mdl-33003597

Assuntos

Carcinoma Hepatocelular/radioterapia; Alcaloides Diterpenos/farmacologia; Neoplasias Hepáticas/radioterapia; Radiossensibilizantes/farmacologia; Agelas/química; Animais; Linhagem Celular Tumoral; Alcaloides Diterpenos/isolamento & purificação; Humanos; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Radiossensibilizantes/isolamento & purificação; Resposta a Proteínas não Dobradas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

(−)-agelamide D; activating transcription factor 4 (ATF4); hepatocellular carcinoma; radiation therapy; unfolded protein response (UPR)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radiossensibilizantes / Carcinoma Hepatocelular / Alcaloides Diterpenos / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article

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